Job

    Chemical/Process Engineer for CMC Chemical Development - Bagsværd, Danmark - Novo Nordisk

    Novo Nordisk
    Novo Nordisk Bagsværd, Danmark

    for 6 dage siden

    Novo Nordisk background
    Beskrivelse
    The position
    As our new Chemical/Process Engineer, you will be instrumental in designing and optimizing synthetic routes for the API.

    You will work closely with a diverse team of chemists, engineers and analytical scientists to ensure robust drug substance manufacture.


    Furthermore, your main responsibilities will include:
    Developing mechanistic models for chemical steps such as reaction, filtration, distillation, extraction, and crystallization. Establishing a Digital Twins for the chemical modification steps. Exploring efficient algorithms for parameter fitting and implementing model-design of experiments. Supporting late-stage development activities, such as control strategy, fate & purge study, PAR, FMEA. Supporting technology transfer to manufacturing sites and process scale-up activities.

    This position gives you a great opportunity to play a part in shaping the future of bioprocessing in close collaboration with a broad variety of stakeholder teams in development, production, and research.

    Qualifications You have a PhD in (chemical) engineering with experience in mechanistic modelling of complex systems based on experimental data supplemented with +3-5 years of experience in the life science industry, preferably in process development and scale-up.


    Furthermore, you should have:

    Strong mathematical and analytical skills, with the ability to formulate mathematical models based on differential equations and apply them using simulation.

    Good understanding of unit operations such as mixing, crystallization, distillation, liquid-liquid extraction and drying. Experience with chemical process development scale-up and/or technical transfer. Knowledge of process safety and Good Manufacturing Practice (GMP) principles.

    Proficiency in modelling software such as Aspen Plus, DynoChem, gPROMS, SuperPro, PRO/II and programming skills in MatLab, Python, or Julia.

    Fluent in English, both written and spoken.

    As a person, you posses exellent communication skills and the ability to present complex results in a clear and concise manner.

    With a solution-oriented mindset you have a strong practical capability to translate theory into real solutions.

    Your positive attitude enables you to work efficiently, whether as a team player or independently, even when dealing with complex tasks, to ensure timely progress.

    You will become part of an international and dynamic team with highly talented and motivated colleagues.

    We have an informal working environment, a strong culture of cross-functional collaboration and knowledge sharing as well as focus on well-being and flexibility in workplace and hours.

    About the area As part of Novo Nordisk PSQIT organisation, Chemistry, Manufacturing and Control (CMC) Development & Scaling makes a real difference for patients with chronic diseases across the world.

    We develop, manufacture and distribute drug candidates for clinical trials and have a strong culture with a "can do" mind-set.

    In Chemical Development, we are responsible for developing the synthetic processes required to produce the active pharmaceutical ingredients (APIs) for Novo Nordisk's new and innovative product portfolio.

    These processes encompass chemical modification of recombinantly-produced proteins, as well as chemical synthesis of peptides, oligonucleotides, small molecules and novel excipients.

    Our work spans various stages of development, from clinical trials to commercial manufacturing.

    Our team in Chemical Development currently consists of 80+ chemists and laboratory technicians, and we have access to state-of-the-art chemistry laboratory facilities in Bagsværd (DK) and offices in Boston (USA).

    Our facilities enable us to support various types of work, including isotope chemistry, scale-up productions, and standard process development. Working at Novo Nordisk Novo Nordisk is its people.

    We know that life is anything but linear and balancing what is important at different stages of our career is never easy.

    That's why we make room for diverse life situations, always putting people first.

    We value our employees for the unique skills they bring to the table, and we work continuously to bring out the best in them.

    Working at Novo Nordisk is working toward something bigger than ourselves, and it's a collective effort. Novo Nordisk relies on the joint potential and collaboration of its more than 60, employees. Together, we go further. Together, we're life changing.
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