PhD in Early Human Brain Development Using Brain Organoids (BB-0C45F)
Found in: Neuvoo DK
PhD in Early Human Brain Development Using Brain Organoids
At the Department of Biochemistry and Molecular Biology Department, University of Southern Denmark we are looking for a PhD student for the above project.
Recently, the possibility to differentiate human iPSCs into organized 3D structures, brain organoids, has provided an efficient tool to study neuronal development in a more advanced model than classic 2D cultures with mature neurons and advanced tissue architecture. Brain organoids are formed by cellular self-organization of neurons and astrocytes, resulting in the formation of distinct and interdependent brain regions ex vivo. Moreover, brain organoids developed over extended periods exhibit active neuronal networks, including the formation of organized and active synapses. The cellular diversity and 3D organization observed in brain organoids represent an advantage for modelling complex interactions observed in the neural microenvironment, including synaptic transmission in synaptosomes.
The project aims at characterizing the molecular processes in developing brain organoids using quantitative proteomics, modification specific proteomics (PTMomics), metabolomics, bioinformatics and imaging.
A successful candidate should preferentially have a Master's or Honour's degree in cell biology, molecular biology, proteomics or a related field and should be highly motivated and innovative. A candidate with significant experience in brain organoids, functional proteomics, post-translational modification analysis, LC-based mass spectrometry and bioinformatics is preferable. Excellent communication and writing skills and an ability to interact socially and scientifically with other laboratory members and collaborators are essential.
Deadline: 26 February 2021.
Please see the full call, including how to apply, on
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work University of Southern Denmark (SDU)