Technical University of Denmark (DTU)

Postdoc positions in Computational Strain Design (BB-461FA)

Found in: Neuvoo DK

Description:

Are you a highly motivated researcher with an interest in computational approaches to strain design and experience in microbial molecular biology, and would like to join our international research center, The Novo Nordisk Foundation for Biosustainability (DTU Biosustain) at the Technical University of Denmark?

Then we may have an interesting opportunity: We are looking for two colleagues in the newly established Strain Design Unit, headed by DTU Biosustain CEO Prof. Bernhard Palsson. This central unit is building cell factories for the various application areas of the Center.

In the Strain Design Unit, we are developing microbial strains for a host of applications, including small molecule production, bioactive compound production, and microbial foods through a combination of experimental and computational design approaches.

Responsibilities and tasks
As computational strain designer, you will build computational workflows for modeling and for omics data analysis for target strain designs. The position requires that you work closely together with DTU-Biosustain’s Principle Investigators and design teams to coordinate schedules and goals for design projects.

Specific tasks include:

  • Utilization of computational tools for the design of microbial strains for various applications.
  • Computational modeling of metabolism to predict strain phenotype and generate strain designs with desired behavior.
  • Statistical analysis of internal and public -omics datasets genomics, transcriptomics, proteomics, metabolomics) to evaluate strain performance.
  • Analysis of genome sequence variations in terms of genetic context as well as protein structural annotation.
  • Participation in a team environment as part of a large academic organization developing computational tools and workflows for strain design.
  • Contribution to development and implementation of computational methods and tools described above.
  • Organization of (bi-)weekly project updates to lab management.

  • Qualifications
  • PhD in bioinformatics, bioengineering or equivalent
  • 2-5 years of experience working or managing in a research organization
  • Familiarity with methods for computational modeling of metabolism, including constraint-based and kinetic modeling
  • Familiarity with machine learning methods, such as elastic net regression, support vector machines, and random forests
  • Familiarity with matrix decomposition techniques, such as Principal Component Analysis and Independent Component Analysis.
  • Intermediate Python/Pandas skills. Experience interfacing databases and R scripting will be an advantage but not required.
  • Demonstrated ability to contribute research and technical content to grant proposals.
  • Ability to communicate technical information to internal/external audiences at various levels (undergraduates to senior scientists) and from various backgrounds (technical and non-technical personnel).
  • Ability to work independently and as part of a team.
  • Ability to successfully work on multiple concurrent projects and meet deadlines.

  • We offer
    At DTU Biosustain we develop the next generation of sustainable biotechnologies using synthetic biology techniques. We create novel production methods and technologies as a foundation for the development of new environmentally friendly products, more energy efficient manufacturing processes, new medical treatments, climate friendly farming, etc.

    DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

    Salary and terms of employment
    The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

    The period of employment is 3 years. Workplace is DTU’s main campus in Kgs. Lyngby, Denmark.

    Further information
    If you would like additional information about the position, please contact Professor Bernhard Palsson, for questions related to science, research and technologies), or Bo Skjold Larsen, questions related to terms of employment).

    You can read more about DTU Biosustain at />

    calendar_today19 minutes ago

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