Danmarks Tekniske Universitet

Postdoc (BB-64ADF)

Found in: Neuvoo DK

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Frist 15. marts 2021
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Post-doctoral position in Immunology starting May 1 2021 available at the Technical University of Denmark (DTU), Department of Health Technology, Section of Experimental and Translational Immunology.
Research Project
The project is titled: The developmental requirements of a new intestinal T cell population.
Interleukin(IL)-17-producing lymphocytes are necessary anti-microbial immune cells against fungi and extracellular bacteria. At the same time, they play a major pathogenic role in chronic inflammation and autoimmunity. Therefore, detailed understanding of their biology can unravel new mechanisms of infectious and inflammatory diseases.
We discovered that a novel IL-17-producing, gut-specific T cell of the gamma delta (γδ) lineage, which, unlike other subsets, co-produces the cytokine interferon(IFN)-γ and develops within the first week of neonatal life (see Kadekar et al, 2020, J Clin Invest; https://doi.org/10.1172/JCI131241). We have confirmed the presence of such intestinal γδT17 cells in human gut, and showed that they are a transcriptionally unique population, expressing genes not previously associated with γδ T cells (unpublished data).
In this project we aim to determine some of the key mechanisms that regulate the development of intestinal γδT17 cells. In this regard, we have designed experiments that will answer: 1) whether intestinal γδT17 cells derive from the thymus or are generated de novo in the gut, 2) whether they strictly require a neonatal microenvironment to develop, 3) when does their progenitor enter the gut, 4) whether the T cell receptor is important for their development and maintenance.
Research group and environment
The project will be carried out in the group of Dr. Vasileios Bekiaris.
At the Department of Health Technology, we have generated a vibrant and very productive research environment in Immunology, with all the required facilities and expertise in most areas of Immunology.
Qualifications
Education
Candidates should hold a PhD in Immunology or relevant discipline.
Research Skills & Expectations
The successful candidate must have demonstrable evidence in:

  • multi-parametric flow cytometry
  • mouse experimentation ( FELASA B training or country equivalent is necessary )
  • isolation of lymphocytes from primary mouse intestine and/or experience with lymphocyte isolation from embryonic and neonatal mouse tissues
  • basic biochemistry and molecular biology
  • A cover letter (max 500 words)
  • Curriculum vitae (max 2 pages): degrees with dates and place must be clearly stated; only relevant previous work experience must be stated; you should state the contact information of at least two academic referees, one of which must be the PhD supervisor.
  • A one-page summary of your PhD thesis
  • Publications list (include pre-prints and manuscripts currently under review)
  • Incomplete applications will not be considered. Candidates may apply prior to ob­tai­ning their PhD degree but cannot begin before having received it.
    All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.
    DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 175 persons, 130 PhD students and a technical/administrative support staff of about 80 persons.
    Technology for people
    DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,000 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.

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